Research Interests 【 display / non-display 】
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Physics and Astronomy
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Machine learning
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Bioinformatics
Graduating School 【 display / non-display 】
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Kyoto University， Faculty of Science
University， 1999.03， Graduated
Graduate School 【 display / non-display 】
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Kyoto University， Graduate School, Division of Natural Science
Doctor's Course， 2004.03， Completed
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Kyoto University， Department of Physics
Doctor's Course， 2004.03， Completed
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Kyoto University， Department of Physics
Doctor's Course， 2001.03， Completed
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Kyoto University， Faculty of Science
Doctor's Course， 1999.03， Completed
Degree 【 display / non-display 】
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Doctor (Science)， Theoretical Particle Physics， Kyoto University， Coursework， 2004.03
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Master(Science)， Natural Science / Theoretical studies related to particle-, nuclear-, cosmic ray and astro-physics， Kyoto University， Coursework， 2001.03
Campus Career 【 display / non-display 】
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Shiga University Faculty of Data science，Professor， 2025.04 - Now
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Shiga University Faculty of Data science，Associate Professor， 2021.04 - 2025.03
External Career 【 display / non-display 】
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Academia Sinica Institute of Physics， Researcher， 2006.08 - 2007.09
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Academia Sinica， Postdoctoral Fellow， 2006.08 - 2007.09
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National Taiwan University National Center for Theoretical Sciences， Researcher， 2004.04 - 2006.07
Research Areas 【 display / non-display 】
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Informatics / Intelligent informatics
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Natural Science / Theoretical studies related to particle-, nuclear-, cosmic ray and astro-physics
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Life Science / System genome science
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Natural Science / Theoretical studies related to particle-, nuclear-, cosmic ray and astro-physics
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Machine Learning
Papers 【 display / non-display 】
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Th17 cells with a pathogenic signature in joints of ZAP-70 mutant arthritic mice harbor unique TCR repertoires that share features with WT Tregs， bioRxiv， 2024.03, Mara Llamas-Covarrubias, Atsushi Tanaka, Martin Loza, Diego Diez, Zichang Xu, Ee Lyn Lim, Shunsuke Teraguchi, Shimon Sakaguchi, Daron Standley
DOI:10.1101/2024.03.01.582868, ， Multiple Authorship
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Robust diagnosis of infectious disease, autoimmunity and cancer from the paratope networks of adaptive immune receptors， bioRxiv， 2023.11
DOI:10.1101/2023.11.28.569125, ， Multiple Authorship
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InterClone: Store, Search and Cluster Adaptive Immune Receptor Repertoires， bioRxiv， 2022.08, Jan Wilamowski, Zichang Xu, Hendra S Ismanto, Songling Li, Shunsuke Teraguchi, Mara Anais Llamas- Covarrubias, Xiuyuan Lu, Sho Yamasaki, Daron Standley
DOI:10.1101/2022.07.31.501809, ， Multiple Authorship
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Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance， International Immunology， vol.31 (11) (p.743 - 753) ， 2019.05, Tomoyuki Yamaguchi, Shunsuke Teraguchi, Chikara Furusawa, Hiroaki Machiyama, Tomonobu M, Watanabe, Hideaki Fujita, Shimon Sakaguchi, Toshio Yanagida
DOI:10.1093/intimm/dxz043, Research paper (scientific journal)， Multiple Authorship
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Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy， Scientific Reports， vol.8 (1) ， 2018.10, Khun Zaw Latt, Kenjiro Honda, Myo Thiri, Yuki Hitomi, Yosuke Omae, Hiromi Sawai, Yosuke Kawai, Shunsuke Teraguchi, Kazuko Ueno, Masao Nagasaki, Akihiko Mabuchi, Hajime Kaga, Atsushi Komatsuda, Katsushi Tokunaga, Eisei Noiri
DOI:10.1038/s41598-018-33612-7, Research paper (scientific journal)， Multiple Authorship
Presentations 【 display / non-display 】
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Domestic presentation， 2020.01，2020.01.11， Structural modeling of T cell receptor and its application， Oral presentation (invited, special)
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IIBMP 2016, Domestic presentation， 2016.09，2016.09.29， Estimation of Diffusion Constants from Single Molecular Measurement without Explicit Tracking， Poster presentation
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Domestic presentation， 2016.07，2016.07.29， Estimation of Diffusion Constants Based on Probabilistic Model of Nearest Neighbors without Explicit Tracking， Oral presentation (invited, special)
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バイオイメージ・インフォマティクスワークショップ 2016, Domestic presentation， 2016.06，2016.06.22， Estimation of Diffusion Constants from Single Molecular Measurement without Explicit Tracking， Oral presentation (general)
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EMBO Workshop, Complex Systems in Immunology, International presentation， 2013.12，2013.12.02， Stochastic binary modeling and network motifs， Poster presentation
Research Grants & Projects 【 display / non-display 】
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，Grant-in-Aid for Scientific Research(C)Grant-in-Aid for Scientific Research(C)，2020.04 - 2023.03
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，Establishment of skin inflammation drug to accumulate high-functional regulatory T cells by single-cell gene expression analysis，Grant-in-Aid for Young Scientists(B)Grant-in-Aid for Young Scientists(B)，2015.04 - 2017.03，Japan Society for the Promotion of Science
We identified several regulatory T cell (Treg) subsets in inflamed skin tissue of mouse line expressing photoconvertible protein KikGR, by which we can distinguish skin-coming and -remaining lymphocytes, by multi-parameter single-cell gene and protein expression analysis. Each subset expressed each set of functional and migration-related molecules and showed different capabilities to remain in inflamed skin. We distinguished skin-coming and -remaining Tregs without KikGR expression data by multi-parameter single-cell expression analysis of functional and migration-related molecules. We also tried to identify master molecules of Treg subset differentiation and establish method to collect the Treg subsets. This research suggests that Tregs expressing different functional molecules showed different migration status in inflamed tissues.
Preferred joint research theme 【 display / non-display 】
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【キーワード】物理学／機械学習、深層学習／データサイエンス
Charge of on-campus class subject 【 display / non-display 】
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データサイエンス上級実践価値創造卒業演習Ⅱ，2025.10 - 2026.03
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データサイエンス実践価値創造演習Ⅱ，2025.10 - 2026.03
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バイオインフォマティクス，2025.10 - 2026.03
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バイオインフォマティクス演習，2025.10 - 2026.03
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応用数学，2025.10 - 2026.03